Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy
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منابع مشابه
Soluble CD30 in early rheumatoid arthritis as a predictor of good response to second-line therapy.
OBJECTIVE To evaluate whether serum levels of the soluble form of CD30 (sCD30) correlate with disease activity in early rheumatoid arthritis (RA) and may have prognostic value in predicting the response to disease-modifying anti-rheumatic drugs (DMARDs). METHODS The levels of sCD30 and C-reactive protein (CRP) were measured in the serum of 14 untreated subjects with early RA, before and durin...
متن کاملCombination second-line therapy for rheumatoid arthritis.
WHILE the treatment of RA has become more aggressive in recent years by the earlier use of second-line agents, remissions, as measured by the ACR [1], resulting from these therapies are rare. Concern has been expressed that the mortality risk in patients with RA is similar to that seen in Stage IV Hodgkin's disease or three vessel coronary artery disease [2]. Certainly, the consideration of dis...
متن کاملOutcome of second line therapy in rheumatoid arthritis.
OBJECTIVES To study the functional outcome in patients with rheumatoid arthritis (RA) who tolerate second line drug therapy for five years. METHODS We enrolled into prospective controlled trials, 190 patients with rheumatoid arthritis who tolerated 'disease modifying' antirheumatic drug therapy for five years. Demographic data were recorded. Disease activity was measured every six months for ...
متن کاملInterferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy.
OBJECTIVE The aim of this study was to use whole transcriptome sequencing (RNA-Seq) of RA neutrophils to identify pre-therapy gene expression signatures that correlate with disease activity or response to TNF inhibitor (TNFi) therapy. METHODS Neutrophils were isolated from the venous blood of RA patients (n = 20) pre-TNFi therapy and from healthy controls (n = 6). RNA was poly(A) selected and...
متن کاملRheumatoid Arthritis: Early diagnosis and treatment outcomes
Rheumatoid arthritis (RA) is an inflammatory progressive disease which in the absence of appropriate treatment can lead to joint destruction and disability. Prognosis of RA may be predicted based on the presence of some clinical and laboratory evidences.New criteria for classification of RA provides opportunity for earlier treatment. Initiation of treatment particularly by combination of DMARDs...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1999
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/38.12.1282